Doxycycline (Doryx)

Description

Doxycycline (Doryx) is a tetracycline antibiotic that inhibits bacterial protein synthesis through binding with the 30S ribosomal subunit
Has activity versus many organisms, including community-acquired methicillin-resistant Staphylococcus aureus, Chlamydia trachomatis, Borrelia burgdorferi (the cause of lyme disease), Plasmodium sp. (the cause of malaria), and Treponema pallidum (the cause of syphilis), Bacillus anthracis (the cause of anthrax), Rickettsia rickettsii (causes rock mountain spotted fever)
Historically has been promoted that it should not be used in persons less than 8 years of age due to potential tooth enamel hypoplasia or permanent tooth discoloration ? HOWEVER, more recent data endorsed by CDC has shown doxycycline is safe for patients less than 8 years of age
Pregnancy category D ? should generally be avoided in pregnancy
Beware phototoxicity, esophagitis and nausea
Available oral and injectable
There are a variety of oral formulations available
100mg twice daily is a common dose and frequency
Can be used as a sclerosing agent
No adjustment needed in dose or frequency for kidney or liver dysfunction