Vagifem (Generic name: Estradiol Vaginal Tablets) is an estrogen therapy used to relieve the symptoms and discomfort associated with atrophic vaginitis, including dryness, soreness, and irritation. The main active ingredient in Vagifem is an estrogen called Estradiol. Estradiol is naturally produced by your body before menopause. Vagifem is the only vaginal tablet available containing estrogen. Vagifem is cleanly and easily inserted into the vagina, providing local treatment of atrophic vaginitis by providing the estrogen lost during menopause. An improvement in symptoms usually occurs after 2 to 3 weeks of treatment. However, it may take up to 7 weeks to feel the full benefits of Vagifem use. Use Estradiol vaginal tablets exactly as it was prescribed for you.